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There is a deeply entangled relationship between Long COVID, metabolic health, and insulin resistance, often referred to as a "pandemic within a pandemic." Viral infections can exacerbate underlying metabolic dysfunction, leading to elevated inflammatory cytokines and poor glucose control

Metformin elevates the miR-34a levels and decreases SIRT1 levels by directly targeting SIRT1 3 -UTR to recover podocyte viability and inhibit podocyte apoptosis (Zhuang et al., 2024)

doi:10.1016/S0140-6736(21)01751-7 [2] Carvas AO, Leuthardt A, Kulka P, et al

Given that most data derive from preclinical models, further well-designed human clinical trials are critical to safely translate these dose-dependent effects into clinical practice, particularly for the prevention and treatment of age-related diseases [248]