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Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor

Patients who are also optimizing hormonal status should be aware that sex hormones interact with MOTS-c signaling

Early studies in the 70s and 80s suggest that glucocorticoids exert essential effects on development, morphology, growth, proliferation, maintenance of vascular tone, and inflammation in smooth muscle and endothelial cells [70,71,72,73,74]