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Disruptions in the intrinsic factor (IF) pathway, including impaired IF production due to autoimmune conditions (pernicious anemia), damage to the ileum from diseases like Crohns or celiac disease, or surgical resection of the ileum, can severely impair B12 absorption

Store small parts in the dedicated storage box in a cool, dry place and avoid direct sunlight

The mechanism involves: Cholinergic antagonism -- cortistatin reduces cortical arousal by antagonizing acetylcholine-mediated excitation, effectively dampening the wake-promoting cholinergic system that maintains cortical desynchronization during wakefulness EEG synchronization -- the transition from wakefulness to SWS is characterized by increasingly synchronized, high-amplitude delta waves on EEG

The solution might be to change the medication or add B12 supplements