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Apart from the vasoconstrictive effects of norepinephrine, its excessive levels increase metalloproteinase (MMP)-14, which promotes the activation of MMP-2 and MMP-9, dissolving numerous endothelial surface molecules such as syndecan-1, glypican-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1) (Figure 4) [86]

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