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Together, these findings support a model in which GSTs exert bidirectional control over pyroptosis with GSTM1 and GSTP1 dampening inflammasome execution, whereas GSTO1 derepresses inflammasome assembly

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Using glutathione or other depigmenting agents without clear medical indication and dermatologic supervision may inadvertently increase vulnerability to sun damage, especially in darker skin tones where pigmentation provides essential photoprotection

The multimer conformations were obtained from alignment to a dimer crystal structure (PDB ID: 3UIW) or self-assembly of free monomers

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[PUBMED Abstract] Gupta S, Teachey DT, Chen Z, et al.: Sex-based disparities in outcome in pediatric acute lymphoblastic leukemia: a Children's Oncology Group report