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CCK causes the gallbladder and, to a lesser extent, common hepatic duct contraction and relaxes the sphincter of Oddi by a direct effect on smooth muscle which is independent of autonomic innervation

81,134,141 ) In addition to perturbations in endogenous RSS metabolism, excessive H 2 S generated via bacterial cysteine desulphydrase from gut microbiota species such as Fusobacterium nucleatum has been linked to the development of colorectal cancer

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