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This approach uses higher daily doses during the first 4 weeks before tapering to maintenance

Improves Mood and depression It helps maintain brain function, and its deficiency can lead to adverse effects such as anxiety and depression

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When your reserves of B12 are low or exhausted, you can easily experience: Failing dental health Bleeding gums Sores in your mouth Diminished or non-existent appetite Digestive problems including constipation, nausea, diarrhea, and/or stomach cramping Experiencing any one symptom can really throw a wrench into the works of your life, but often a person with a vitamin B12 deficiency will experience multiple symptoms at once

Funding This work was supported by National Natural Science Foundation of China (81771140), Youth Medical Talent Program of Jiangsu Province (QNRC2016068), and Medical Innovation Team of Jiangsu Province (CXTDA2017030)

Functional medicine uses narrower ranges and assesses cortisol in the context of the full diurnal curve rather than a single number