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The delivery system not only improves the water solubility and bioavailability of sorafenib, but also increases the accumulation of the drug in the tumor site through an active targeting mechanism, thereby maintaining efficacy at lower doses and reducing toxic reactions (Table 2)

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Larger individuals with more adipose tissue benefit from doses at the upper end of standard ranges

Elevated GSH levels have been observed in many cancers and were associated with chemoresistance