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When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein

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The alignment of GPX amino acid residues under biotic stress revealed conserved cysteine residues essential for catalytic activity within motifs 1 and 2 (red triangles, Figure 7 )

developed a dual-target ADC for EpCAM and CLDN3, which requires high co-expression of both antigens on tumors for effective killing, exhibiting minimal toxicity to normal cells that only highly express EpCAM but have low CLDN3 levels, thereby alleviating the toxicity limitations of single-target EpCAM ADCs [138]