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Cultural factors further complicate this picture, with some cultures viewing menstrual pain as a normal part of womanhood that should be accepted rather than questioned (Moradi et al., 2014)

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Harris AP, Holmes MC, de Kloet ER, Chapman KE, Seckl JR (2013)

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The tip of the microvilli is always relatively hypoxic compared to the base, and in reduced perfusion states, oxygen will tend to move down a gradient from arteriole to venule closer to the base, thus exacerbating hypoxia at the tip and potentially switching apoptosis to necrosis in epithelial cells

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Transdermal drug delivery: innovative pharmaceutical developments based on disruption of the barrier properties of the stratum corneum

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