why does a b12 injection hurt Shots Side Effects And How To Treat Them Do B12 Injections Hurt? Painful
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Those taking certain medications - PPI medication, such as omeprazole, can reduce acid production in the stomach

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Evening dosing is generally avoided since some patients report disturbed sleep onset after taking AOD 9604 late in the day

Intramuscular injections deliver B12 directly into muscle, which allows it to enter the bloodstream and bypass digestive absorption problems (NIH ODS)
As a water-soluble vitamin, excess B12 is excreted in urine, and no upper limit has been set in the UK due to its low toxicity
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