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An additional study (TERIS) utilizing teriflunomide 14 mg daily versus placebo also demonstrated a delay in time to the first clinical event in patients with radiologically isolated syndrome (64)

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For histological and immunohistochemical analyses, the individual animal was treated as the experimental unit, and values from multiple sections or fields were averaged per animal prior to analysis

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At least three independent experiments were performed to obtain at least three K I values of the testing peptide
