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The most frequent symptoms are: Developmental delays Anaemia Loss of appetite Chronic vomiting Weight loss Low brain volume Spasms/cramps Apathy Irritability In the most severe instance, vitamin B12 deficiency can lead to respiratory failures and coma (51)

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Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies

This is acceptable in many cases, but there are important caveats

Safety & Side Effects Regarded as safe, including urinary-derived forms no prion transmission risk noted