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Yes, MIC B12 injections generally require refrigeration between 36F and 46F (2C to 8C) to maintain chemical stability and potency

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National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

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But for most individuals, its puzzling to understand precisely how long it takes before they notice a difference once they begin B12 supplements or injections

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Eksperimental'naia i Klinicheskaia Farmakologiia, 78 (1), 13-15

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Reducing cholesterol

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Pregnancy Category C: Animal reproduction studies have not been conducted with vitamin B12

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