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Individual hypersensitivity is often considered the most common yet manageable risk, and the majority of herbal medicines are generally recognized as safe

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Male C57BL/6J mice (n = 32) were group housed (n = 45 per cage)

Abbreviations ADA: AdE1-LMPpoly vaccine AE: Adverse event APC: Antigen-presenting cell APL: Altered peptide ligand ARR: Annualized relapse rate BBB: Blood-brain barrier BTK: Brutons tyrosine kinase CAR T: Chimeric antigen receptor T-cell CD: Cluster of differentiation CNS: Central nervous system CSF: Cerebrospinal fluid DMT: Disease-modifying therapy EBNA: EpsteinBarr Nuclear Antigen EBV: EpsteinBarr virus EDSS: Expanded Disability Status Scale FMT: Fecal microbiota transplantation Gd + : Gadolinium-enhancing lesions HSCT: Hematopoietic stem cell transplantation ICANS: Immune effector cell-associated neurotoxicity syndrome IFN-1a: Interferon beta-1a IL: Interleukin MOG: Myelin oligodendrocyte glycoprotein MRI: Magnetic resonance imaging MSC: Mesenchymal stem cell MS: Multiple sclerosis NEDA: No evidence of disease activity NMOSD: Neuromyelitis optica spectrum disorder OPC: Oligodendrocyte precursor cell PML: Progressive multifocal leukoencephalopathy RR: Risk ratio RRMS: Relapsing-remitting multiple sclerosis SAE: Serious adverse event SCFA: Short-chain fatty acid S1P: Sphingosine-1-phosphate SPMS: Secondary progressive multiple sclerosis TEAE: Treatment-emergent adverse event Treg: Regulatory T cell VEP: Visual evoked potential References Ahmed Z, Fulton D, Douglas MR (2020) Opicinumab: is it a potential treatment for multiple sclerosis