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FDA noted that reviewed CoAs from suppliers did not consistently include controls for impurities, aggregates, or bacterial endotoxins

You need 2.6 micrograms of B12 daily while pregnant and 2.8 mcg while breastfeeding

Small, geographically dispersed patient populations and high phenotypic variability often lead to slow recruitment, limited statistical power, and extended trial durations 30,31,32,33,34

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