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Xiong YJ, Song YZ, Zhu Y, Zuo WQ, Zhao YF, Shen X, et al

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found that TMAO enhanced thrombosis risk by reanalyzing the clinical data of 4,007 subjects ( Recent investigations have demonstrated that TMAO enhances platelet reactivity by promoting ERK1/2 and Jun N-terminal kinase (JNK) phosphorylation ( In vivo and in vitro experiments have revealed that TMAO increases thrombotic potential by strengthening aortic vascular tissue factor (TF) and vascular cell adhesion molecule (VCAM)1 expression ( TMAO Promotes Foam Cell Formation Foam cells are the main component of atherosclerotic plaques