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10.1016/j.cell.2016.02.011 77

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Late-onset hyperammonaemia in children, adolescents or adults can result from a partial or mild deficiency in a urea cycle enzyme that is exacerbated by certain stressors

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These mechanisms plausibly influence behavioral domains (irritability, hyperactivity, sociability, language, sleep) and interact with gastrointestinal comorbidities and barrier integrity