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Although elevated BL are well known for its neurotoxic role, physiological concentration appears to confer protection against neuroinflammation ( 2.2.2.1 BL modulates innate immunity in PD The innate immune system plays a central role in the pathogenesis of PD ( Notably, TLR4 ablation impairs microglial phagocytosis of -Syn, facilitating its pathological accumulation ( In PD, elevated intracellular free Fe 2+ leads to microglial iron overload, driving excessive ROS production, increased release of IL-1 and TNF-, and enhanced -Syn aggregation ( Emerging evidence suggests that BL can abnormally activate TRPM2 channels, leading to pathological calcium influx and microglial overactivation

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