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Numerous preclinical studies with pharmacological Nrf2 activators (e.g., sulforaphane, naringenin, curcumin) have demonstrated significant cardioprotection in MIRI models, attenuating injury, reducing infarct size, and decreasing oxidative stress, inflammation, and cell death (Wang R

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A tightly controlled metal homeostasis network is needed to adjust fluctuations in metal availability in order to ensure proper distribution of metals and prevent toxic metal accumulation

Aloysia citrodora leaf EO (main compounds limonene, 1,8-cineole and geranial) has demonstrated dose-dependent iron-chelating capability [75]

[Google Scholar] 14.Khare A., Moss G.P., Weedon B.C., Matthews A.D

Nature 320 , 8485 (1986)