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On the third day after IONI, the amount of IGF-1 released by macrophages in ION and TG increased significantly

Glutathione-S-Transferases (GST) GSTs belong to the Phase II biotransformation enzymes catalyzing the GSH-mediated peroxide reduction [194] and conjugation of GSH with a variety of reactive electrophiles, most commonly generated by cytochrome P450 metabolism [195]

De Koning, T

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GSH treatment led to a significant increase in PDH phosphorylation in PDP1-silenced cells compared to the corresponding untreated control (Supplementary Figure S5), suggesting that endogenous ROS levels at 21% O 2 are sufficient to reversibly inhibit PDP1

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