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Major modifications for 2025 As outlined in the 2025 Summary of Major Modifications and Explanatory Notes, the major modifications for 2025 include the following: Further examples were added to the following substance classes to help athletes and their entourage better identify prohibited substances: S0

There are some exceptions: ruminants can produce it in their second stomach through the microbiota present there (requiring a micronutritional dietary precursor, cobalt), or fish from their producing microbiota, through the intake of phytoplankton, or by eating other fish

It can correct deficiency-related fatigue, but it is not a stimulant

The deficiency of inositol can sometimes lead to hair loss

There is no doubt than even unexpired opened vials deteriorate over time

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