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Mechanical allodynia was assessed using an electronic von Frey Anesthesimeter (IITC-Life Science Instruments, Woodland Hill, CA) as described by Caplan et al

If a significant part of this mechanism relies on re-absorption from bile that would be an issue due to lack of intrinsic factor breaking the "enterohepatic recirculation"

Replenishing systemic stores may restore normal oxidative capacity and improves metabolic homeostasis in deficient states

This is highly speculative because: Oral bioavailability differs between species Route of administration affects systemic exposure Species differences in peptide metabolism and clearance are unknown Current Practice Patterns Current practice patterns from unregulated sources typically involve: Subcutaneous injection: 0.25-0.5 mg once or twice daily, administered near injection sites for localized effects or abdominally for systemic distribution

Injection site irritation may increase slightly since you are adding a daily injection to your routine, but site rotation prevents this from becoming an issue

While HbA1c remains a common tool, recognizing its potential in signaling neuropathy necessitates further evaluation and timely interventions