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Thus, Gly 2 may be feasible if a dual agonist is biosynthesized

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Patients start at the lowest available dose and increase it every four weeks until they reach the maximum dose of 2.4mg

This double-blind, randomized, 26-week superiority trial compared 2 mg of exenatide injection once weekly plus oral placebo (n = 160), 100 mg of oral sitagliptin plus once-weekly injected placebo (n = 166), and 45 mg of oral pioglitazone once-daily plus once-weekly injected placebo (n = 165)

Although both drug classes could theoretically offer neuroprotective benefits based on their mechanisms of action, RCTs have provided mixed or inconclusive results

The combination of improved blood pressure with a modest heart rate increase represents a net cardiovascular benefit for most individuals, but monitoring remains essential for those with pre-existing conditions