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The first obstacle is the difficulty in finding sufficient funding for conventional iron depletion by phlebotomy, and the second one is the impossibility of running blind studies together with the presence of many confounders by using phlebotomy

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[90] Although both molecules can have biological effects, thyroxine (T 4 ) is considered the "storage form" of thyroid hormone with much less effect, while tri-iodothyronine (T 3 ) is considered the active form used by body tissues

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Time on ART also impacted on the AM cellular response to stress via inactivation of reactive oxygen species (ROS) and protein turnover via the unfolded protein response (UPR) ( Figure 4B )
