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Description
B12 deficiency causes fatigue, anemia, and neurologic symptoms, and is more common in older adults, vegans, and those with malabsorption conditions

Furthermore, phase II studies were undertaken to prove the efficacy of mecasermin rinfabate (IGF-1/IGFBP-3) in paediatric severe burns and had promising outcomes when doses of 14 mg/kg/day [269273] were used

Bariatric Surgery and Vitamin B Deficiency 4.1

Most shots are 1000 mcg/mL

That's why most research protocols build in a break between cycles, often called a washout period, to let the body reset before starting again
Discovery Medicine