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6 Owners may note the light-gray appearance of stool, which in combination with icterus is virtually diagnostic for extrahepatic cholestasis

In addition, supplementing the intake of fruits, vegetables, and grains may provide additional benefits such as micronutrients that were not considered in our study

Clinical studies have consistently shown curcumins safety, tolerability, and effectiveness in managing various chronic human illnesses (237) reported no adverse effects in humans after orally administering 6 g of curcumin per day for 47 weeks

Discussion In this study, we demonstrated that OA mice exhibit a lower level of H 2 S in synovial fluid and plasma compared with SHAM mice in vivo and GYY4137 can effectively suppress DMM-induced synovial macrophage pyroptosis and cartilage degeneration

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