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The maximum concentrations (C max ) of each dose were 12.3, 48.9, and 141 ng/ml, respectively, and the AUC 0t values were 75.1, 289, and 1930 ng min/ml, respectively

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The critical caveat: rodent fat metabolism differs substantially from human fat metabolism

Recently available directional leads would also help us to reduce energy consumption and prolong battery life, avoid side effects related to high DBS settings, and make more precise stimulation possible

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