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Current consensus suggests astrocytes maintain vascular tone equilibrium (between vasodilation and vasoconstriction) under physiological conditions

6 Formalin-induced nociceptive behavioral test Male Sprague Dawley rats (250~300 g) (n = 35) were randomly divided into the control (n = 7), 5 mg/kg morphine (n = 7) and BPC-157 groups (n = 21) to establish the inflammatory pain model and conduct the behavior test

p-mTOR: phosphorylated mammalian target of rapamycin

The disruption of mechanisms such as oligodendrocyte maturation and migration, myelin phagocytosis, myelin sheath renewal and the inflammation itself are consonant with the full pathological progression of demyelination

Example #2

The anti-inflammatory properties of phytochemicals and their effects on epigenetic mechanisms involved in TLR4/NF-B-Mediated inflammation