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Description
Following GPx-mediated H 2 O 2 consumption, residual hydrogen peroxide undergoes Fenton-type redox reactions with Fe 2+ ions, generating Fe + species that coordinate with Tiron through catechol moieties to form a stable ferri-Tiron complex [Fe(C 6 H 4 Na 2 O 8 S 2 )] +
Today 57 , 309316 (2022)
23 It also binds to glutathione peroxidase to reduce production of lipid peroxide
Participants gave written informed consent at the start of the trial
10.1016/j.phrs.2015.03.010 69 GrealishS.DiguetE.KirkebyA.MattssonB.HeuerA.BramoulleY.et al (2014)
Whether this translates to humans is unresolved, so the label contraindicates it in the highest-risk groups as a precaution
