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Many osmolytes do not directly interact with proteins but exhibit osmoprotectant activity by excluding them from the protein surface (i.e., osmophobic effect), allowing proteins to fold correctly (Singh et al., 2007)

doi: 10.1016/j.ejheart.2003.12.004 21 CroninP.JoyceS

The significant prevalence of depression in patients with acquired hypothyroidism, coupled with the high susceptibility to developing depression and anxiety, highlights the need for enhanced monitoring of psychiatric symptoms

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Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range

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