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NNMT consumes S-adenosylmethionine (SAM) and methylates nicotinamide, depleting cellular methyl pools and downstream NAD+ precursors
Research has explored the compounds role in adipocyte systems, including investigations into lipid accumulation patterns and related metabolic processes
This restoration of metabolic cofactor availability enables enhanced function of NAD+-dependent enzymes including sirtuins, poly(ADP-ribose) polymerases, and various deacetylases that regulate cellular metabolism, stress responses, and aging processes
Typical research applications include: Investigation of NNMT inhibition and its role in metabolic regulation
COA included
