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In most cases, this is more relevant to pigmentation-related response and receptor sensitivity than to the neuroendocrine or sexual-arousal pathways more strongly linked to other melanocortin receptors in the brain

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Following PKC-mediated phosphorylation the MARCKS protein leaves the membrane and migrates to the cytosol where it modulates cytoskeletal actin dynamics and vesicular trafficking resulting in the activation various signal transduction pathways

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4 Early virologic response is a 2 log decrease in HCV RNA from baseline