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Most importantly, these were in accordance with the identified particular vascular target for successful therapy in the rat glaucoma, retinal ischemia, and corneal ulcers (i.e., episcleral veins, central retinal artery)

doi: 10.4103/jhrs.JHRS_95_18 3 MoranLTeedeH

doi: 10.1126/science.1470919 79
Alehagen U, Opstad TB, Alexander J, Larsson A, Aaseth J

These substitutes may be more dependence forming (such as methamphetamine), or more prone to induce overdose (such as methaqualone at grossly elevated dosages) or having properties seemingly antagonistic to those of MDMA (such as ketamine)

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