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2001 Sep;33(9):1415-22

The following parameters were evaluated and scored on a scale from 0 to 3: 1- Follicular degeneration, 2- Inflammation, 3- Hemorrhage, 4- Edema, 5- Vascular congestion

A recent clinical trial with oral administration of NAC did not demonstrate increased GSH levels in some brain regions measured by 1 H-MRS [140]

When autophagy is dysfunctional, it causes intracellular p62 accumulation, leading to the activation of the Nrf2 pathway and thus compensating for the lack of autophagy [83, 84]

Ovine proinflammatory cytokines cross the murine blood-brain barrier by a common saturable transport mechanism
