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In human liver microsomes, the main CYPs responsible for the formation of 9( Z ),12( Z )-11-HODE are CYP1A2 and CYP3A4

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Therefore, despite the fact that decreasing the dosing frequency from q1wk to q2wk decreases the total amount of drug taken over time by one half, the model predicts that patients retain 72% of their weight loss compared with q1wk