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FIGURE 3 3.5 Disease-gene network correlates hub OS-DEGs with multi-disease associations underlying cellular stress mechanisms The disease-gene association network highlights hub genes including GPx4, SOD1, SOD2, ATM, CAT, TP53, SNCA, FOS, G6PD, IL6, EDN1, HSPB1, and MPO as critical hubs involved in OS-related diseases (Figure 3C)

Free Radic Biol Med 50: 874882 Han ES, Muller FL, Prez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J et al (2008) The in vivo gene expression signature of oxidative stress

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