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AGEs react with amino acid residues in proteins, forming irreversible modifications that negatively affect sperm, including reduced sperm count, decreased motility, increased morphological abnormalities, residual histones, fish sperm protein deficiency, sperm DNA fragmentation, decreased antioxidant capacity in the testes, and elevated levels of receptor for advanced glycation end products (RAGE) and carboxymethyl lysine (CML) proteins [160]

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Administration of GSTP recombinant protein (2 mg/kg, i.p.) to both wild type and Gstp / mice 30 min after CLP surgery significantly alleviated CLP-induced acute lung injury, decreased HMGB1 release and mortality of mice (Figures 1AC)

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PMID: 9834227

Activation of family C G-protein-coupled receptors by the tripeptide glutathione