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In the 1950s, researchers began to focus on pain-relieving effects from vitamin B12 administration with some potentially impressive clinical results (3,4), although study methodologies were not robust and some studies on other pain conditions showed no effects (5)

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Pyridoxine should not be administered at doses above 5 mg / day to patients receiving levodopa only

Premawardhana, A

Use once daily, 12 sprays (625mcg - 1250mcg), with up to 80 uses per bottle