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In AIDs, HIF-1-mediated angiogenesis may augment blood perfusion within damaged tissues, ameliorating local hypoxia, yet potentially fostering the infiltration of inflammatory cells and exacerbating autoimmune responses (210)

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Dienel and Cruz (2003, 2004) further argued that cerebral metabolic rates of oxygen consumption do not equal that of glucose plus glycogen and that this disproportionate consumption is strong evidence against stoichiometric transfer of lactate from astrocytes to neighboring neurons for oxidation