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In the olfactory nerve pathway, therapeutic agents absorbed from the olfactory epithelium diffuse through the CSF surrounding the brain via perineural channels

This makes it a potential therapeutic option for conditions such as inflammatory bowel disease (IBD), peptic ulcers, and gastroesophageal reflux disease (GERD), where maintaining gut health is paramount for symptom management and overall well-being
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doi: 10.1111/j.1365-2982.2010.01498.x 28 BoleijAHechenbleiknerEMGoodwinACBadaniRSteinEMLazarevMGet al

Vitamin B12 is required for normal cell function, so a deficiency over a long period of time may impact growth, digestion, blood cell production, and the nervous system

People on vegan or strict plant-based diets need a reliable source from fortified foods (nutritional yeast, fortified plant milks, certain breakfast cereals) or a supplement
