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It has been noted that patients with PD and AD have higher levels of total CSF homocysteine but not free Homocysteine (Isobe et al
Therefore, GPX4-mediated ferroptosis may be a promising target for treating major depressive disorder

2 Elevated ROS levels result in overactivation of key signaling pathways such as extracellular-regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK), and phosphatidyl inositol 3 kinases (PI3Ks), which are crucial for regulating cell survival and propagation

Journal of cardiothoracic and vascular anesthesia, 2011
