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It is characterized by deleterious alterations in the NF1 tumor suppressor gene at 17q11.2, resulting in heterozygous, loss-of-function mutations

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Cronin SJF, Woolf CJ, Weiss G, Penninger JM

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Research indicates it may also have effects on appetite regulation and metabolic processes through its interaction with other melanocortin receptor subtypes

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It may be flat or slightly elevated and is usually well demarcated from the surrounding tissue [5, 39, 40]

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