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231 Additionally, approximately one-third of the pathological mutations observed in the gene encoding tau (MAPT) have been reported to affect tau splicing and the ratio of tau isoforms containing three or four microtubule-binding domains (3R-tau to 4R-tau ratio)a ratio whose imbalance is linked to impaired microtubule dynamics in tauopathies such as AD

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Analysis of selected samples by HPLC with electrochemical detection [42] demonstrated that total GSH was comprised of approximately 95% GSH and GSSG levels were low and unchanged as a result of EtOH administration

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261,262 Following activation by hypoxia, recent evidence indicates that leukocytes exacerbate the inflammatory microenvironment

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