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This section provides a comprehensive overview of the pretreatment, extraction, separation, and purification techniques for various types of HEP that have been reported in the recent literature

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1 Introduction Despite decades of intensive research and substantial investmentwith Alzheimers disease alone projected to surpass 1 trillion USD in global cost by 2050 (Nandi et al., 2024), therapeutic progress in neurodegenerative disorders has remained limited, with most clinical approaches continuing to target downstream proteinopathies and yielding only modest effects on disease trajectories (Selkoe and Hardy, 2016

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Intravenous fluids will help prevent dehydration and help maintain pressure

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No significant genotype-dependent differences were observed (Additional file 1: Fig

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Neurobiological and Systemic Effects of Chronic Stress

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Certain neuroactive compounds directly activate hypothalamic neurons, including GnRH neurons 196,220 (Fig

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