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Hormones such as glucagon bind to plasma membrane receptors on liver cells, activating membrane-localized adenylate cyclase leading to an increase in the conversion of ATP to cAMP (see diagram below)

Computational identification and quantification of proteins Spectral matching to peptides, grouping of peptide identifications into proteins, and isobaric label quantification were performed using Proteome Discoverer 2.1 (Thermo)

Wang et al., 2025

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