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ROS also induce the release of matrix metalloproteinases (MMPs), enzymes that damage the extracellular matrix and affect tissue integrity (Sukriti et al., 2014

In addition, thioselenide is produced on PRDX6 via an inorganic selenide pathway that functions independently of PLP, further contributing to selenoprotein synthesis (Chen et al, 2024

Through proliferation experiments, Liu et al [] found that quercetin had cytotoxic effects on GEM-resistant cell lines (HepG2 and PANC-1), and flow cytometry analysis showed that quercetin had significant pro-apoptotic effects