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High circulating levels of the IGF-1R ligand IGF-1 can also activate IGF-1R signaling and is correlated with increased risk of prostate [43], ovarian [44], and breast cancer [45], as well as possibly second primary cancers [46]
Paul Rozance and colleagues at the Perinatal Research Center at Childrens Hospital Colorado, included two cohorts

10.1038/s41401-020-00589-x [DOI] [PMC free article] [PubMed] [Google Scholar] 7.Chen N, Liu J, Qiao Z, Liu Y, Yang Y, Jiang C, et al

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