lung cancer glutathione levels peroxidase 8 (GPX8) was involved in CAFs‐mediated migration reduced glutathione and breast cancer

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The protein P53 also plays a significant role in PD pathogenesis

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The antioxidant enzymes glutathioneperoxidase, catalase, and superoxide dismutase (SOD) metabolize oxidative toxic intermediates

Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H, et al

As the primary factors for the reduced anticancer effect 1) the reduced delivery and uptake of the anticancer agent, 2) the need for the conversion of molecular oxygen (O 2 ) into reactive oxygen species (ROS), 3) the preferred therapeutic effect against highly proliferating cells, which is reduced under hypoxic conditions, or 4) adaptation of the cancer cells by promoting cell survival and upregulating certain resistance pathways, has been suggested 1,2,3,4,5