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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Heijmans J, Wielenga MCB, Rosekrans SL, van Lidth de Jeude JF, Roelofs J, Groothuis P, Ederveen A, de Jonge-Muller ESM, Biemond I, Hardwick JCH, DHaens G, Hommes DW, Muncan V, van den Brink GR

These pathways are particularly significant for macromolecules and surface-modified particulate systems, where ligand attachment or mucoadhesive coatings may enhance epithelial interaction and promote uptake, thereby increasing the likelihood of transport via olfactory and trigeminal neuronal pathways (Dhuria et al., 2010, Pardeshi and Belgamwar, 2013)

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